The Substance

"A fading celebrity decides to use a black market drug, a cell-replicating substance that temporarily creates a younger, better version of herself."

Cast

Demi Moore

as Elisabeth

Margaret Qualley

as Sue

Dennis Quaid

as Harvey

Edward Hamilton-Clark

as Fred

Gore Abrams

as Oliver

Oscar Lesage

as Troy

Christian Erickson

as Man at Diner

Robin Greer

as Male Nurse

Tom Morton

as Doctor

Hugo Diego Garcia

as Diego - Boyfriend

Daniel Knight

as Casting Director

Jonathon Carley

as Assistant Casting Director

Jiselle Henderkott

as Girl Auditioning / New Year's Eve Show Dancer

Akil Wingate

as TV Host

Vincent Colombe

as Man in Suit #1 - Harvey's Office

Billy Bentley

as Man in Suit #2

Lennard Ridsdale

as Man in Suit #3

Jordan Ford Silver

as Assistant Director - Pump It Up Show

Oscar Salem

as 2nd Assistant Director - Pump It Up Show

Viviane Bossina

as Sue's Assistant

Matthew Luret

as Floor Runner

Jana Bittnerová

as Maria

Olivier Raynal

as Alan - 2nd Agent

Tiffany Hofstetter

as Stylist

Nicolas Royer

as Guy in the Elevator

Nathan Rippy

as Assistant Director - New Year's Eve Show

Manon Arizmendi

as Little Girl - New Year's Eve Show

Virginie Kotlinski

as Mother - New Year's Eve Show

Brett Gillen

as Director of Photography - New Year's Eve Show

Charlotte Marquardt

as Screaming Woman

Léa Hengl

as Screaming Woman

Gaëlle Raymond

as Screaming Woman

Claire Lemaire

as Screaming Woman

Lila Boughoufala

as Screaming Woman

Aurélien Lorgnier

as Screaming Man

Ivan Sellier

as Screaming Man

Philip Schurer

as Screaming Man

Christian Bourmier

as Shareholder

Martin Graham

as Shareholder

Christian Bordeleau

as Shareholder

Patrick Hamel

as Shareholder

Didier Dhondt

as Shareholder

Jacques-Yves Dorges

as Shareholder

Jean-Claude Matthey

as Shareholder

Olivier Jarcin

as Shareholder

Jean-Luc Magneron

as Shareholder

Charlotte Murray

as Allison - Diner Waitress

Aaron Kahn

as Greeting Person

Gabriela Arnon

as Greeting Person

Nancy Josephson Lahoussine

as Greeting Person

Andrew Eldridge

as Greeting Person

Denise Powers

as Greeting Person

Bryan Jones

as Greeting Person

Adam Carage

as Happy Birthday Person

Maria McClurg

as Happy Birthday Person

Andrew Desmond

as Happy Birthday Person

Rebecca Lafont

as Happy Birthday Person

Laura Puech

as Isabella

Ryan Chidester

as Stagehand

Cécile Vogt

as Elisabeth (Young) - Walk of Fame / Pump It Up Show Dancer

Yannick Guérin

as Clumsy Burger Guy - Walk of Fame

Jean Miel

as Worker Walk of Fame

Paul Descoings

as Worker Walk of Fame

Benoit Lévêque

as Worker Walk of Fame

Arthur Molinet

as Cocktail Bartender

Manon Sachot

as Cocktail Lounge Couple

Bastien Jorelle

as Cocktail Lounge Couple

Kelly Hoarau

as Female Assistant - Towel

Michel Juskiewicz

as George - Harvey's Friend

Louise Greggory

as Restaurant Waitress

Christophe Sartirano

as Guy Looking at Sue

Florent Torres

as Guy Looking at Sue

Romain Caldeira

as Billboard Technician

Barthelemy Thomas

as Billboard Technician

Axel Baille

as Photographer

Ashley Lambert

as Additional Voices (voice)

Ranjani Brow

as Additional Voices (voice)

Chase Fein

as Additional Voices (voice)

Shane Sweet

as Additional Voices (voice)

William Calvert

as Additional Voices (voice)

Michael Corbett

as Additional Voices (voice)

Stephen Apostolina

as Additional Voices (voice)

Yann Bean

as The Substance (voice)

Audjyan Alcide

as Pump It Up Show Dancer

Jonathan Jenvrin

as Pump It Up Show Dancer

Mimi Maury

as Pump It Up Show Dancer

Amelye Solange

as Pump It Up Show Dancer

Kévin Table

as Pump It Up Show Dancer

Laura Boera

as Sparkle Your Life Show Dancer

Cissy Duc

as Sparkle Your Life Show Dancer

Sophie Mercier

as Sparkle Your Life Show Dancer

Marie Valton

as Sparkle Your Life Show Dancer

Katrina Budzynski

as New Year's Eve Show Dancer

Alicia Maury

as New Year's Eve Show Dancer

Megane Adamik

as New Year's Eve Show Dancer

Annalisa Pagnotta

as New Year's Eve Show Dancer

Maelle Dantigny

as New Year's Eve Show Dancer

Aleksandra Kedzierska Fontaine

as New Year's Eve Show Dancer

Pauline Sagetat

as New Year's Eve Show Dancer

Agustina Fitzsimons

as New Year's Eve Show Dancer

Elena Shcheglova

as New Year's Eve Show Dancer

Eve Marchant

as New Year's Eve Show Dancer

Lola Donati

as New Year's Eve Show Dancer

Kate Matthews

as New Year's Eve Show Dancer

Ophélie Jonard

as New Year's Eve Show Dancer

Pauline Richard

as New Year's Eve Show Dancer

Laureen Cappelliez

as New Year's Eve Show Dancer

Daria Panchenko

as New Year's Eve Show Dancer

Delphine Beaulieu

as New Year's Eve Show Dancer

Victoria Brun

as New Year's Eve Show Dancer

Cara Chapman

as New Year's Eve Show Dancer

Katharine Matthews

as New Year's Eve Show Dancer

Alexandra Faget

as New Year's Eve Show Dancer

Clémence Juville

as New Year's Eve Show Dancer

Margot L'Entete

as New Year's Eve Show Dancer

Hillary Sukhonos

as New Year's Eve Show Dancer

Matthew Géczy

as Bob Haswell (uncredited)

Namory Bakayoko

as Silhouette (uncredited)

Gregory Defleur

as Happy Birthday Person (uncredited)

Coralie Fargeat

as (uncredited)

Crew

Anne Juin

Third Assistant Director

Matthieu de la Mortière

First Assistant Director

Erik Baiers

Executive Producer

Stanislas Reydellet

Production Design

Jérôme Gaspard

Stunt Coordinator

Sebastian Lochmann

Concept Artist

Richard Martin

Prosthetics Sculptor

Frédérique Arguello

Hair Department Head

Benjamin Kračun

Director of Photography

Marie Bouvet

Stunt Double

Frédéric Balmer

Special Effects Makeup Artist

Andrea Leanza

Prosthetics Sculptor

Krystell Morantin

Assistant Art Director

Denise Boccacci

Prosthetic Makeup Artist

Bryan Jones

Visual Effects Supervisor

Jérôme Eltabet

Editor

Cécilia Blom

Set Decoration

Joffrey Darel

Stunt Driver

Céline Richard

Stunts

Catherine Georges

Camera Operator

Camille Damag

Costume Supervisor

Fabienne Menguy

Costume Supervisor

Baptiste Bonin

Props

Guillemette Buffet

Stunt Double

Stephane Girondeaud

Stunts

Steve de Rocco

Camera Operator

Arthur Delapierre

Stunts

Marie Sergeant

Stunts

Ahmed Chouikhi

Stunts

Chloè Acher

Second Assistant Camera

Yann Festinger

Video Assist Operator

Noémie Lance

Location Manager

Eddy Trouillot

Grip

Laure Caniaux

First Assistant Camera

Nahi Margot

Electrician

Olivier Maurin

Electrician

Nadege Marti

Location Scout

Benjamin Bouygues-Faugeron

Property Buyer

Benjamin Colleye

Additional First Assistant Camera

Tanguy Goasguen

Additional Grip

Gustin Guillaume

First Assistant Camera

Baptiste Herment

Production Accountant

Olivier Sargatal

Best Boy Electric

Lucile Perez

Stunts

Vianne Burquier

Camera Intern

Marie-Sophie Daniel

First Assistant Camera

Jonas Poignant

Third Assistant Camera

Guillaume Lemerle

Gaffer

Baptiste Marnière

Digital Imaging Technician

Edouard Alvernhe

Electrician

Stella Libert

First Assistant Camera

Fabien Pascal

Colorist

Benjamin Durfort

Assistant Editor

Jérémie Delaboudinière

Stunts

Thomas Gros

Key Grip

William Renaud

Grip

Katia Sourzac

Location Production Assistant

Charles Droudun

Electrician

Ludovic Tobaldi

Steadicam Operator

Christine Tamalet

Still Photographer

Coralie Fargeat

Director

Coralie Fargeat

Producer

Tim Bevan

Producer

Eric Fellner

Producer

Alexandra Loewy

Executive Producer

Nicolas Royer

Executive Producer

Raffertie

Original Music Composer

Marison De

Special Effects Makeup Artist

Olivier Afonso

Special Effects Makeup Artist

Sandrine Denis

Special Effects Makeup Artist

Oriane Cattiaux

Makeup Artist

Benjamin Celliez

Unit Production Manager

Julia Besnier

Production Accountant

Clément Audebrand

Third Assistant Director

Pierre-Yves Frohard

Production Coordinator

Abraham Goldblat

Post Production Supervisor

Barthelemy Thomas

Set Dresser

Caroline Vlieghe

Hairstylist

Dave Elsey

Prosthetic Supervisor

Lou Elsey

Prosthetic Supervisor

Louis Celnik

Carpenter

Benoit Seiller

Second Assistant Director

Marion Didier

Assistant Art Director

Cynthia Scigliuto

Makeup Artist

Honorine Sutter

Assistant Production Manager

Elise Duvignau

Props

Stéphanie Guillon

Key Makeup Artist

Bryony Rumble

Special Effects Makeup Artist

Mateo Cejoco

Third Assistant Director

Mélissa Jacob

Additional Hairstylist

Lucky Nguyen

Makeup Artist

Coralie Fargeat

Editor

Tiva Nagchin

Post Production Supervisor

Louis Tellier

Third Assistant Director

Brian Kinney

Special Effects Makeup Artist

Amélie Meseguer

Assistant Set Decoration

Jean Miel

Special Effects Supervisor

Marianne Huet

Script Supervisor

Guillaume Le Gouez

Visual Effects Supervisor

Guillaume Billy

Camera Trainee

Raphaëlle Beck

Extras Casting

Elsa Manunta

Set Costumer

Guillaume Baurez

Music Supervisor

Chloé Zobel

Property Master

Jacob Rogers

Digital Compositor

Jacques-Emmanuel Astor

Extras Casting

Jimmy Zhao

First Assistant Editor

Marjane Texier

Graphic Designer

Elsa Rolland

Assistant Property Master

Christophe Arnaud

Additional Second Assistant Camera

Steve Sebir

Assistant Location Manager

Louis Auger

Digital Compositor

Thomas Burgess

Steadicam Operator

Olaf Taittinger

Special Effects

Téo L'Huillier

Digital Compositor

Louis Lion

Digital Compositor

Christophe Riso

Assistant Location Manager

Isalys Gillet

Location Assistant

Aurélie Boutet

Casting Assistant

Pierre-Olivier Persin

Prosthetics

Pierre-Olivier Persin

Makeup Effects Designer

Stéphane Bécimol

Art Direction

Marion De Villechabrolle

Set Decoration

Valentin Féron

Editor

Emmanuelle Youchnovski

Costume Designer

Valérie Deloof

Sound Designer

Patrick Christensen

ADR Mixer

Olga Pasternak

Supervising Dialogue Editor

Thomas Pichon

Dialogue Editor

Anna Devillaire

ADR Editor

Margaux Peyre

Boom Operator

Grégory Vincent

Foley Artist

Stéphane Thiébaut

Sound Re-Recording Mixer

Victor Fleurant

Sound Editor

Judah Getz

ADR Mixer

Antoine Swertvaegher

Foley Editor

Victor Praud

Sound Re-Recording Mixer

Emmanuelle Villard

Sound Mixer

Valérie Deloof

Sound Editor

Claire Bernengo

Boom Operator

Lucien Richardson

Supervising Dialogue Editor

Laure Cochener

Casting

Coralie Fargeat

Writer

Amélie Meseguer

Art Direction

Arnaud Denis

Art Direction

Gladys Garot

Art Direction

Julie Plumelle

Art Direction

Nathalie Vaïsse

Art Direction

Pierre Procoudine-Gorsky

Visual Effects Producer

Chevin Shafaghi

Visual Effects Supervisor

Serafin Bernfeld

Special Effects Technician

Arthur Weiser

Special Effects Technician

Alexandrine Mauvezin-Bosque

Set Dresser

Marilyne Scarselli

Key Hair Stylist

Jean-Marc Benois

Additional Hairstylist

Frédérique Arguello

Key Hair Stylist